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The osteogenesis-promoting effects of alpha-lipoic acid against glucocorticoid-induced osteoporosis through the NOX4, NF-kappaB, JNK and PI3K/AKT pathways

Recently, accumulating evidence has indicated that glucocorticoid-induced osteoporosis (GIOP) is closely related to oxidative stress and apoptosis. Alpha-lipoic acid (LA), a naturally endogenous anti-oxidant, possesses anti-oxidative and anti-apoptosis activities, implicating LA as a therapeutic age...

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Autores principales: Lu, Shi-Yu, Wang, Chang-Yuan, Jin, Yue, Meng, Qiang, Liu, Qi, Liu, Zhi-hao, Liu, Ke-Xin, Sun, Hui-Jun, Liu, Mo-Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469800/
https://www.ncbi.nlm.nih.gov/pubmed/28611356
http://dx.doi.org/10.1038/s41598-017-03187-w
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author Lu, Shi-Yu
Wang, Chang-Yuan
Jin, Yue
Meng, Qiang
Liu, Qi
Liu, Zhi-hao
Liu, Ke-Xin
Sun, Hui-Jun
Liu, Mo-Zhen
author_facet Lu, Shi-Yu
Wang, Chang-Yuan
Jin, Yue
Meng, Qiang
Liu, Qi
Liu, Zhi-hao
Liu, Ke-Xin
Sun, Hui-Jun
Liu, Mo-Zhen
author_sort Lu, Shi-Yu
collection PubMed
description Recently, accumulating evidence has indicated that glucocorticoid-induced osteoporosis (GIOP) is closely related to oxidative stress and apoptosis. Alpha-lipoic acid (LA), a naturally endogenous anti-oxidant, possesses anti-oxidative and anti-apoptosis activities, implicating LA as a therapeutic agent for the treatment of GIOP. In this study, the osteogenesis-promoting effects of LA against GIOP were investigated and the mechanisms were further probed. Here, the results showed that LA inhibited oxidative stress, suppressed apoptosis and improved osteopenia by promoting the expression of osteogenesis markers, including ALP, COL-I, OCN, BMP-2, RUNX2 and OSX. Further study revealed that the osteogenesis-promoting effects of LA likely occur via the regulation of the NOX4, NF-kappaB, JNK and PI3K/AKT pathways. The present study indicated that LA may prevent GIOP and promote osteogenesis and might be a candidate for the treatment of GIOP.
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spelling pubmed-54698002017-06-19 The osteogenesis-promoting effects of alpha-lipoic acid against glucocorticoid-induced osteoporosis through the NOX4, NF-kappaB, JNK and PI3K/AKT pathways Lu, Shi-Yu Wang, Chang-Yuan Jin, Yue Meng, Qiang Liu, Qi Liu, Zhi-hao Liu, Ke-Xin Sun, Hui-Jun Liu, Mo-Zhen Sci Rep Article Recently, accumulating evidence has indicated that glucocorticoid-induced osteoporosis (GIOP) is closely related to oxidative stress and apoptosis. Alpha-lipoic acid (LA), a naturally endogenous anti-oxidant, possesses anti-oxidative and anti-apoptosis activities, implicating LA as a therapeutic agent for the treatment of GIOP. In this study, the osteogenesis-promoting effects of LA against GIOP were investigated and the mechanisms were further probed. Here, the results showed that LA inhibited oxidative stress, suppressed apoptosis and improved osteopenia by promoting the expression of osteogenesis markers, including ALP, COL-I, OCN, BMP-2, RUNX2 and OSX. Further study revealed that the osteogenesis-promoting effects of LA likely occur via the regulation of the NOX4, NF-kappaB, JNK and PI3K/AKT pathways. The present study indicated that LA may prevent GIOP and promote osteogenesis and might be a candidate for the treatment of GIOP. Nature Publishing Group UK 2017-06-13 /pmc/articles/PMC5469800/ /pubmed/28611356 http://dx.doi.org/10.1038/s41598-017-03187-w Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Lu, Shi-Yu
Wang, Chang-Yuan
Jin, Yue
Meng, Qiang
Liu, Qi
Liu, Zhi-hao
Liu, Ke-Xin
Sun, Hui-Jun
Liu, Mo-Zhen
The osteogenesis-promoting effects of alpha-lipoic acid against glucocorticoid-induced osteoporosis through the NOX4, NF-kappaB, JNK and PI3K/AKT pathways
title The osteogenesis-promoting effects of alpha-lipoic acid against glucocorticoid-induced osteoporosis through the NOX4, NF-kappaB, JNK and PI3K/AKT pathways
title_full The osteogenesis-promoting effects of alpha-lipoic acid against glucocorticoid-induced osteoporosis through the NOX4, NF-kappaB, JNK and PI3K/AKT pathways
title_fullStr The osteogenesis-promoting effects of alpha-lipoic acid against glucocorticoid-induced osteoporosis through the NOX4, NF-kappaB, JNK and PI3K/AKT pathways
title_full_unstemmed The osteogenesis-promoting effects of alpha-lipoic acid against glucocorticoid-induced osteoporosis through the NOX4, NF-kappaB, JNK and PI3K/AKT pathways
title_short The osteogenesis-promoting effects of alpha-lipoic acid against glucocorticoid-induced osteoporosis through the NOX4, NF-kappaB, JNK and PI3K/AKT pathways
title_sort osteogenesis-promoting effects of alpha-lipoic acid against glucocorticoid-induced osteoporosis through the nox4, nf-kappab, jnk and pi3k/akt pathways
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469800/
https://www.ncbi.nlm.nih.gov/pubmed/28611356
http://dx.doi.org/10.1038/s41598-017-03187-w
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