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Integrin α2β1 in nonactivated conformation can induce focal adhesion kinase signaling
Conformational activation of integrins is generally required for ligand binding and cellular signalling. However, we have previously reported that the nonactivated conformation of α2β1 integrin can also bind to large ligands, such as human echovirus 1. In this study, we show that the interaction bet...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469853/ https://www.ncbi.nlm.nih.gov/pubmed/28611383 http://dx.doi.org/10.1038/s41598-017-03640-w |