Fibroblastic reticular cells of the lymphoid tissues modulate T cell activation threshold during homeostasis via hyperactive cyclooxygenase-2/prostaglandin E(2) axis

Fibroblastic reticular cells (FRCs) in the T cell zone of lymph nodes (LNs) are pivotal for T cell survival, mobility, and peripheral tolerance. Here, we demonstrate that during homeostasis, FRCs also suppress T cell activation via producing high level of prostaglandin E(2) (PGE(2)) due to their tho...

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Detalles Bibliográficos
Autores principales: Yu, Miao, Guo, Gang, Zhang, Xin, Li, Li, Yang, Wei, Bollag, Roni, Cui, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469856/
https://www.ncbi.nlm.nih.gov/pubmed/28611431
http://dx.doi.org/10.1038/s41598-017-03459-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469856/
https://www.ncbi.nlm.nih.gov/pubmed/28611431
http://dx.doi.org/10.1038/s41598-017-03459-5

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