Hepatocellular Toxicity Associated with Tyrosine Kinase Inhibitors: Mitochondrial Damage and Inhibition of Glycolysis

Tyrosine kinase inhibitors (TKIs) are anticancer drugs with a lesser toxicity than classical chemotherapeutic agents but still with a narrow therapeutic window. While hepatotoxicity is known for most TKIs, underlying mechanisms remain mostly unclear. We therefore aimed at investigating mechanisms of...

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Detalles Bibliográficos
Autores principales: Paech, Franziska, Bouitbir, Jamal, Krähenbühl, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469902/
https://www.ncbi.nlm.nih.gov/pubmed/28659801
http://dx.doi.org/10.3389/fphar.2017.00367

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469902/
https://www.ncbi.nlm.nih.gov/pubmed/28659801
http://dx.doi.org/10.3389/fphar.2017.00367

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