MYO6 Regulates Spatial Organization of Signaling Endosomes Driving AKT Activation and Actin Dynamics

APPL1- and RAB5-positive signaling endosomes play a crucial role in the activation of AKT in response to extracellular stimuli. Myosin VI (MYO6) and two of its cargo adaptor proteins, GIPC and TOM1/TOM1L2, localize to these peripheral endosomes and mediate endosome association with cortical actin fi...

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Detalles Bibliográficos
Autores principales: Masters, Thomas A., Tumbarello, David A., Chibalina, Margarita V., Buss, Folma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469940/
https://www.ncbi.nlm.nih.gov/pubmed/28591580
http://dx.doi.org/10.1016/j.celrep.2017.05.048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469940/
https://www.ncbi.nlm.nih.gov/pubmed/28591580
http://dx.doi.org/10.1016/j.celrep.2017.05.048

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