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Simulation of complex data structures for planning of studies with focus on biomarker comparison

BACKGROUND: There are a growing number of observational studies that do not only focus on single biomarkers for predicting an outcome event, but address questions in a multivariable setting. For example, when quantifying the added value of new biomarkers in addition to established risk factors, the...

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Detalles Bibliográficos
Autores principales: Schulz, Andreas, Zöller, Daniela, Nickels, Stefan, Beutel, Manfred E., Blettner, Maria, Wild, Philipp S., Binder, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470184/
https://www.ncbi.nlm.nih.gov/pubmed/28610631
http://dx.doi.org/10.1186/s12874-017-0364-y