Unexpected consequences: exon skipping caused by CRISPR-generated mutations

A new study finds that splicing disruption is a frequent consequence of mutations generated by CRISPR/Cas9 gene-editing technology, and alleles designed to be null can express aberrant proteins. This new information allows enhanced quality control procedures to select the best mutant alleles generat...

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Detalles Bibliográficos
Autores principales: Sharpe, Joshua J., Cooper, Thomas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470267/
https://www.ncbi.nlm.nih.gov/pubmed/28615035
http://dx.doi.org/10.1186/s13059-017-1240-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470267/
https://www.ncbi.nlm.nih.gov/pubmed/28615035
http://dx.doi.org/10.1186/s13059-017-1240-0

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