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Unexpected consequences: exon skipping caused by CRISPR-generated mutations
A new study finds that splicing disruption is a frequent consequence of mutations generated by CRISPR/Cas9 gene-editing technology, and alleles designed to be null can express aberrant proteins. This new information allows enhanced quality control procedures to select the best mutant alleles generat...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470267/ https://www.ncbi.nlm.nih.gov/pubmed/28615035 http://dx.doi.org/10.1186/s13059-017-1240-0 |