Janus Compounds, 5-Chloro-N(4)-methyl-N(4)-aryl-9H-pyrimido[4,5-b]indole-2,4-diamines, Cause Both Microtubule Depolymerizing and Stabilizing Effects

While evaluating a large library of compounds designed to inhibit microtubule polymerization, we identified four compounds that have unique effects on microtubules. These compounds cause mixed effects reminiscent of both microtubule depolymerizers and stabilizers. Immunofluorescence evaluations show...

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Detalles Bibliográficos
Autores principales: Rohena, Cristina C., Risinger, April L., Devambatla, Ravi Kumar Vyas, Dybdal-Hargreaves, Nicholas F., Kaul, Roma, Choudhary, Shruti, Gangjee, Aleem, Mooberry, Susan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470396/
https://www.ncbi.nlm.nih.gov/pubmed/27918450
http://dx.doi.org/10.3390/molecules21121661

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470396/
https://www.ncbi.nlm.nih.gov/pubmed/27918450
http://dx.doi.org/10.3390/molecules21121661

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