Progerin impairs vascular smooth muscle cell growth via the DNA damage response pathway

Mutations of the lamin A gene cause various premature aging syndromes, including Hutchinson-Gilford progeria syndrome (HGPS) and atypical Werner syndrome. In HGPS (but not atypical Werner syndrome), extensive loss of vascular smooth muscle cells leads to myocardial infarction with premature death. T...

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Detalles Bibliográficos
Autores principales: Kinoshita, Daisuke, Nagasawa, Ayako, Shimizu, Ippei, Ito, Takashi K., Yoshida, Yohko, Tsuchida, Masanori, Iwama, Atsushi, Hayano, Toshiya, Minamino, Tohru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470950/
https://www.ncbi.nlm.nih.gov/pubmed/28423660
http://dx.doi.org/10.18632/oncotarget.15973

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470950/
https://www.ncbi.nlm.nih.gov/pubmed/28423660
http://dx.doi.org/10.18632/oncotarget.15973

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