Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice

Doxorubicin is the chemotherapeutic drug of choice for a wide variety of cancers, and cardiotoxicity is one of the major side effects of doxorubicin treatment. One of the main cellular targets of doxorubicin in the heart is mitochondria. Mitochondrial sirtuin, SIRT3 has been shown to protect against...

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Detalles Bibliográficos
Autores principales: Pillai, Vinodkumar B., Kanwal, Abhinav, Fang, Yong Hu, Sharp, Willard W., Samant, Sadhana, Arbiser, Jack, Gupta, Mahesh P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper: Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470953/
https://www.ncbi.nlm.nih.gov/pubmed/28423723
http://dx.doi.org/10.18632/oncotarget.16133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470953/
https://www.ncbi.nlm.nih.gov/pubmed/28423723
http://dx.doi.org/10.18632/oncotarget.16133

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