Cargando…

Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice

Doxorubicin is the chemotherapeutic drug of choice for a wide variety of cancers, and cardiotoxicity is one of the major side effects of doxorubicin treatment. One of the main cellular targets of doxorubicin in the heart is mitochondria. Mitochondrial sirtuin, SIRT3 has been shown to protect against...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pillai, Vinodkumar B., Kanwal, Abhinav, Fang, Yong Hu, Sharp, Willard W., Samant, Sadhana, Arbiser, Jack, Gupta, Mahesh P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper: Pathology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470953/ https://www.ncbi.nlm.nih.gov/pubmed/28423723 http://dx.doi.org/10.18632/oncotarget.16133

Ejemplares similares

Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial SIRT3
por: Pillai, Vinodkumar B., et al.
Publicado: (2015)

Skeletal muscle‐specific over‐expression of the nuclear sirtuin SIRT6 blocks cancer‐associated cachexia by regulating multiple targets
por: Samant, Sadhana A., et al.
Publicado: (2020)

The histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy
por: Samant, Sadhana A., et al.
Publicado: (2017)

The nuclear sirtuin SIRT6 protects the heart from developing aging-associated myocyte senescence and cardiac hypertrophy
por: Pillai, Vinodkumar B., et al.
Publicado: (2021)

SIRT3 is attenuated in systemic sclerosis skin and lungs, and its pharmacologic activation mitigates organ fibrosis
por: Akamata, Kaname, et al.
Publicado: (2016)

Honokiol bis-dichloroacetate (Honokiol DCA) demonstrates activity in vemurafenib-resistant melanoma in vivo
por: Bonner, Michael Y., et al.
Publicado: (2016)

MST1 mediates doxorubicin-induced cardiomyopathy by SIRT3 downregulation
por: Schirone, Leonardo, et al.
Publicado: (2023)

SIRT3 activator Honokiol attenuates β-Amyloid by modulating amyloidogenic pathway
por: Ramesh, Sindhu, et al.
Publicado: (2018)

Honokiol ameliorates radiation-induced brain injury via the activation of SIRT3
por: Liao, Guixiang, et al.
Publicado: (2020)

Honokiol attenuates lipotoxicity in hepatocytes via activating SIRT3-AMPK mediated lipophagy
por: Liu, Jingxin, et al.
Publicado: (2021)

Honokiol Inhibits Atrial Metabolic Remodeling in Atrial Fibrillation Through Sirt3 Pathway
por: Liu, Guang Zhong, et al.
Publicado: (2022)

Honokiol attenuates mitochondrial fission and cell apoptosis by activating Sirt3 in intracerebral hemorrhage
por: Zheng, Xuecheng, et al.
Publicado: (2023)

SIRT3 Activator Honokiol Inhibits Th17 Cell Differentiation and Alleviates Colitis
por: Chen, Xiaotian, et al.
Publicado: (2023)

Detection of the nonsense mutation of OPA3 gene in Holstein Friesian cattle with dilated cardiomyopathy in Japan
por: HORIUCHI, Noriyuki, et al.
Publicado: (2015)

Honokiol is a FOXM1 antagonist
por: Halasi, Marianna, et al.
Publicado: (2018)

Mitochondria and Doxorubicin-Induced Cardiomyopathy: A Complex Interplay
por: Schirone, Leonardo, et al.
Publicado: (2022)

Sirtuin 3 (SIRT3) Pathways in Age-Related Cardiovascular and Neurodegenerative Diseases
por: Silaghi, Ciprian N., et al.
Publicado: (2021)

Honokiol antagonizes doxorubicin-induced cardiomyocyte senescence by inhibiting TXNIP-mediated NLRP3 inflammasome activation
por: Huang, Pian-Pian, et al.
Publicado: (2020)

Activation of sirtuin 1/3 improves vascular hyporeactivity in severe hemorrhagic shock by alleviation of mitochondrial damage
por: Li, Pengyun, et al.
Publicado: (2015)

Impact of the Dual Deletion of the Mitochondrial Sirtuins SIRT3 and SIRT5 on Anti-microbial Host Defenses
por: Heinonen, Tytti, et al.
Publicado: (2019)

Sirtuin-3 (SIRT3), a Novel Potential Therapeutic Target for Oral Cancer
por: Alhazzazi, Turki Y, et al.
Publicado: (2011)

Sirtuins and SIRT6 in Carcinogenesis and in Diet
por: de Céu Teixeira, Maria, et al.
Publicado: (2019)

Takotsubo Cardiomyopathy: Understanding the Pathophysiology of Selective Left Ventricular Involvement
por: Pasupula, Deepak Kumar, et al.
Publicado: (2019)

Melatonin Restores Autophagic Flux by Activating the Sirt3/TFEB Signaling Pathway to Attenuate Doxorubicin-Induced Cardiomyopathy
por: Ma, Yanyan, et al.
Publicado: (2023)

Sirtuin (Sirt) 3 Overexpression Prevents Retinopathy in Streptozotocin-Induced Diabetic Rats
por: Mao, Xin-bang, et al.
Publicado: (2020)

Seeding for sirtuins: microseed matrix seeding to obtain crystals of human Sirt3 and Sirt2 suitable for soaking
por: Rumpf, Tobias, et al.
Publicado: (2015)

Sirtuin-3 (SIRT3), a therapeutic target with oncogenic and tumor-suppressive function in cancer
por: Chen, Y, et al.
Publicado: (2014)

The Role of Sirtuin 1 (SIRT1) in Neurodegeneration
por: Razick, Daniel I, et al.
Publicado: (2023)

Honokiol inhibits the growth of SKBR3 cells
por: Shi, He, et al.
Publicado: (2020)

Dual Deletion of the Sirtuins SIRT2 and SIRT3 Impacts on Metabolism and Inflammatory Responses of Macrophages and Protects From Endotoxemia
por: Heinonen, Tytti, et al.
Publicado: (2019)

Assessing sirtuin expression in endometrial carcinoma and non-neoplastic endometrium
por: Bartosch, Carla, et al.
Publicado: (2015)

Distinct role of Sirtuin 1 (SIRT1) and Sirtuin 2 (SIRT2) in inhibiting cargo-loading and release of extracellular vesicles
por: Lee, Byung Rho, et al.
Publicado: (2019)

A Plasma Cell Dyscrasia Presenting as Amyloid Cardiomyopathy and Autonomic Dysfunction in a Healthy Patient
por: Tabet, Rabih, et al.
Publicado: (2017)

Mechanism of Inhibition of the Human Sirtuin Enzyme SIRT3 by Nicotinamide: Computational and Experimental Studies
por: Guan, Xiangying, et al.
Publicado: (2014)

Sirtuin 3 Alleviates Diabetic Cardiomyopathy by Regulating TIGAR and Cardiomyocyte Metabolism
por: Li, Lanfang, et al.
Publicado: (2021)

Honokiol protects against doxorubicin cardiotoxicity via improving mitochondrial function in mouse hearts
por: Huang, Lizhen, et al.
Publicado: (2017)

EFFECT OF L-VALINE TREATMENT ON SIRTUIN (SIRT1 AND SIRT2) ISOFORMS
por: Sharma, Shakshi, et al.
Publicado: (2022)

Efficacy of Modified Masood Scoring System (MMSS) in Cytological Diagnosis of Breast Lesions
por: William, Justina, et al.
Publicado: (2022)

Naproxen aggravates doxorubicin-induced cardiomyopathy in rats
por: Pathan, Rahila Ahmad, et al.
Publicado: (2010)

Pro-Apoptotic Activity of New Honokiol/Triphenylmethane Analogues in B-Cell Lymphoid Malignancies
por: Mędra, Aleksandra, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_bp36nrsukbb1rctq81gvsc0sfp