Inhibitor of Tec kinase, LFM-A13, decreases pro-inflammatory mediators production in LPS-stimulated RAW264.7 macrophages via NF-κB pathway

Tec kinase, a prototypical member of the Tec tyrosine kinases family, was shown to mainly govern lymphocyte proliferation. In the present study, we investigated the role of Tec kinase in acute inflammatory response in lipopolysaccharide (LPS) challenge. First, we demonstrate that Tec kinase activity...

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Detalles Bibliográficos
Autores principales: Wang, Fei, Zhang, Wei, Wang, Chao, Fang, Xu, Cheng, Hao, Liu, Sheng, Chen, Xu-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper: Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470954/
https://www.ncbi.nlm.nih.gov/pubmed/28415764
http://dx.doi.org/10.18632/oncotarget.16212

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470954/
https://www.ncbi.nlm.nih.gov/pubmed/28415764
http://dx.doi.org/10.18632/oncotarget.16212

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