CRISPR Cas9-guided chromatin immunoprecipitation identifies miR483 as an epigenetic modulator of IGF2 imprinting in tumors

The normally imprinted insulin-like growth factor II (IGF2) gene is aberrantly upregulated in a variety of human malignancies, yet the mechanisms underlying this dysregulation are still poorly defined. In this report, we used a CRISPR Cas9-guided chromatin immunoprecipitation assay to characterize t...

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Detalles Bibliográficos
Autores principales: Zhang, Yiqun, Hu, Ji-Fan, Wang, Hong, Cui, Jiuwei, Gao, Sujun, Hoffman, Andrew R., Li, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470959/
https://www.ncbi.nlm.nih.gov/pubmed/27486969
http://dx.doi.org/10.18632/oncotarget.10918

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470959/
https://www.ncbi.nlm.nih.gov/pubmed/27486969
http://dx.doi.org/10.18632/oncotarget.10918

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