Detection of COPB2 as a KRAS synthetic lethal partner through integration of functional genomics screens

Mutated KRAS plays an important role in many cancers. Although targeting KRAS directly is difficult, indirect inactivation via synthetic lethal partners (SLPs) is promising. Yet to date, there are no SLPs from high-throughput RNAi screening, which are supported by multiple screens. Here, we address...

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Detalles Bibliográficos
Autores principales: Christodoulou, Eleni G., Yang, Hai, Lademann, Franziska, Pilarsky, Christian, Beyer, Andreas, Schroeder, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470967/
https://www.ncbi.nlm.nih.gov/pubmed/28415695
http://dx.doi.org/10.18632/oncotarget.16079

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470967/
https://www.ncbi.nlm.nih.gov/pubmed/28415695
http://dx.doi.org/10.18632/oncotarget.16079

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