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BALB/c mice immunized with a combination of virus-like particles incorporating Kaposi sarcoma-associated herpesvirus (KSHV) envelope glycoproteins gpK8.1, gB, and gH/gL induced comparable serum neutralizing antibody activity to UV-inactivated KSHV

Infection with Kaposi sarcoma-associated herpesvirus (KSHV) is estimated to account for over 44,000 new cases of Kaposi sarcoma annually, with 84% occurring in Africa, where the virus is endemic. To date, there is no prophylactic vaccine against KSHV. KSHV gpK8.1, gB, and gH/gL glycoproteins, implic...

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Detalles Bibliográficos
Autores principales: Barasa, Anne K, Ye, Peng, Phelps, Meredith, Arivudainambi, Ganapathiram T, Tison, Timelia, Ogembo, Javier Gordon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470984/
https://www.ncbi.nlm.nih.gov/pubmed/28404899
http://dx.doi.org/10.18632/oncotarget.15605