Small molecules targeting histone demethylase genes (KDMs) inhibit growth of temozolomide-resistant glioblastoma cells

In glioblastoma several histone demethylase genes (KDM) are overexpressed compared to normal brain tissue and the development of Temozolomide (TMZ) resistance is accompanied by the transient further increased expression of KDM5A and other KDMs following a mechanism that we defined as “epigenetic res...

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Detalles Bibliográficos
Autores principales: Banelli, Barbara, Daga, Antonio, Forlani, Alessandra, Allemanni, Giorgio, Marubbi, Daniela, Pistillo, Maria Pia, Profumo, Aldo, Romani, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471020/
https://www.ncbi.nlm.nih.gov/pubmed/28432280
http://dx.doi.org/10.18632/oncotarget.16820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471020/
https://www.ncbi.nlm.nih.gov/pubmed/28432280
http://dx.doi.org/10.18632/oncotarget.16820

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