Cargando…

Loss-of-function myostatin mutation increases insulin sensitivity and browning of white fat in Meishan pigs

Myostatin-deficient mice showed a remarkable hypertrophy of skeletal muscle, with a decreased fat mass and enhanced insulin sensitivity. Currently, it is unclear if the inhibition of myostatin could be used as an approach to treat human obesity and insulin resistance. In this study, we investigated...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cai, Chunbo, Qian, Lili, Jiang, Shengwang, Sun, Youde, Wang, Qingqing, Ma, Dezun, Xiao, Gaojun, Li, Biao, Xie, Shanshan, Gao, Ting, Chen, Yaoxing, Liu, Jie, An, Xiaorong, Cui, Wentao, Li, Kui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471021/ https://www.ncbi.nlm.nih.gov/pubmed/28432282 http://dx.doi.org/10.18632/oncotarget.16822

Ejemplares similares

Targeted mutations in myostatin by zinc-finger nucleases result in double-muscled phenotype in Meishan pigs
por: Qian, Lili, et al.
Publicado: (2015)

Gene Location, Expression, and Function of FNDC5 in Meishan Pigs
por: Cai, Chunbo, et al.
Publicado: (2017)

Over-Expression of Porcine Myostatin Missense Mutant Leads to A Gender Difference in Skeletal Muscle Growth between Transgenic Male and Female Mice
por: Ma, Dezun, et al.
Publicado: (2015)

Effect of ZFN-edited myostatin loss-of-function mutation on gut microbiota in Meishan pigs
por: Cui, Wen-Tao, et al.
Publicado: (2019)

MicroRNA-95 promotes myogenic differentiation by down-regulation of aminoacyl-tRNA synthase complex-interacting multifunctional protein 2
por: Li, Biao, et al.
Publicado: (2017)

Safety Evaluation of Neo Transgenic Pigs by Studying Changes in Gut Microbiota Using High-Throughput Sequencing Technology
por: Wang, Qingqing, et al.
Publicado: (2016)

Differential transcriptional analysis between red and white skeletal muscle of Chinese Meishan pigs
por: Li, Yang, et al.
Publicado: (2010)

Identification of a differentially expressed gene, ACL, between Meishan × Large White and Large White × Meishan F1 hybrids and their parents
por: Ren, Zhu-Qing, et al.
Publicado: (2008)

Solexa Sequencing Identification of Conserved and Novel microRNAs in Backfat of Large White and Chinese Meishan Pigs
por: Chen, Chen, et al.
Publicado: (2012)

A porcine gene, PBK, differentially expressed in the longissimus muscle from Meishan and Large White pig
por: Yonggang, Liu, et al.
Publicado: (2009)

Identification of Ovarian Circular RNAs and Differential Expression Analysis between MeiShan and Large White Pigs
por: Liang, Guoming, et al.
Publicado: (2020)

A further look at quantitative trait loci affecting growth and fatness in a cross between Meishan and Large White pig populations
por: Quintanilla, Raquel, et al.
Publicado: (2002)

Fecal microbial composition associated with testosterone in the development of Meishan male pigs
por: Jiang, Xueyuan, et al.
Publicado: (2023)

Integrated Microbiome and Metabolome Analysis Reveals a Positive Change in the Intestinal Environment of Myostatin Edited Large White Pigs
por: Pei, Yangli, et al.
Publicado: (2021)

Inhibition of in vitro and in vivo brown fat differentiation program by myostatin
por: Braga, Melissa, et al.
Publicado: (2013)

Estimation of crossbreeding parameters between Large White and Meishan porcine breeds
por: Bidanel, JP, et al.
Publicado: (1989)

Length polymorphism in OGT between Korean native pig, Chinese Meishan, and the Western pig breeds
por: Nam, Yoon Seok, et al.
Publicado: (2015)

The complete mitochondrial genome sequence of Meishan pig (Sus Scrofa) and a phylogenetic study
por: Dong, Lianhua, et al.
Publicado: (2016)

Myostatin Alteration in Pigs Enhances the Deposition of Long-Chain Unsaturated Fatty Acids in Subcutaneous Fat
por: Pei, Yangli, et al.
Publicado: (2022)

Proteomic Analysis of Fetal Ovary Reveals That Ovarian Developmental Potential Is Greater in Meishan Pigs than in Yorkshire Pigs
por: Xu, Mengmeng, et al.
Publicado: (2015)

Molecular cloning, spatial and temporal expression analysis of CatSper genes in the Chinese Meishan pigs
por: Song, Chengyi, et al.
Publicado: (2011)

Growth, carcass and meat quality performance of crossbred pigs with graded proportions of Meishan genes
por: Bidanel, JP, et al.
Publicado: (1993)

Endometrial gene expression profiling in pregnant Meishan and Yorkshire pigs on day 12 of gestation
por: Gu, Ting, et al.
Publicado: (2014)

An Integrative ATAC-Seq and RNA-Seq Analysis of the Endometrial Tissues of Meishan and Duroc Pigs
por: Zhang, Han, et al.
Publicado: (2023)

CNV analysis of Meishan pig by next-generation sequencing and effects of AHR gene CNV on pig reproductive traits
por: Zheng, Xianrui, et al.
Publicado: (2020)

Regulation of brown adipocyte metabolism by myostatin/follistatin signaling
por: Singh, Rajan, et al.
Publicado: (2014)

Detection of Placental Proteomes at Different Uterine Positions in Large White and Meishan Gilts on Gestational Day 90
por: Che, Long, et al.
Publicado: (2016)

Myostatin signals through miR-34a to regulate Fndc5 expression and browning of white adipocytes
por: Ge, X, et al.
Publicado: (2017)

Transcriptome Analysis Revealed the Embryo-Induced Gene Expression Patterns in the Endometrium from Meishan and Yorkshire Pigs
por: Huang, Jiangnan, et al.
Publicado: (2015)

Evidence of evolutionary history and selective sweeps in the genome of Meishan pig reveals its genetic and phenotypic characterization
por: Zhao, Pengju, et al.
Publicado: (2018)

Analysis of Structural Variants Reveal Novel Selective Regions in the Genome of Meishan Pigs by Whole Genome Sequencing
por: Du, Heng, et al.
Publicado: (2021)

Conjoint analysis of transcriptome and metabolome profiles of normal captivity and arch soil free-range in Meishan pigs
por: Liu, Ying, et al.
Publicado: (2023)

Combining two Meishan F2 crosses improves the detection of QTL on pig chromosomes 2, 4 and 6
por: Tortereau, Flavie, et al.
Publicado: (2010)

Transcriptome-Wide lncRNA and mRNA Profiling of Spleens from Meishan Pigs at Different Development Stages
por: Xu, Chao, et al.
Publicado: (2022)

Genome-wide analysis of circRNA regulation during spleen development of Chinese indigenous breed Meishan pigs
por: Wang, Yifu, et al.
Publicado: (2023)

Dietary energy intake affects fetal survival and development during early and middle pregnancy in Large White and Meishan gilts
por: Che, Long, et al.
Publicado: (2015)

A genome-wide linkage analysis for reproductive traits in F(2) Large White × Meishan cross gilts
por: Hernandez, S C, et al.
Publicado: (2014)

Genome-wide genetic structure and differentially selected regions among Landrace, Erhualian, and Meishan pigs using specific-locus amplified fragment sequencing
por: Li, Zhen, et al.
Publicado: (2017)

Factors Associated with White Fat Browning: New Regulators of Lipid Metabolism
por: Zhang, Peiwen, et al.
Publicado: (2022)

Synchronous onset of oestradiol-17β secretion by Meishan conceptuses
por: Pickard, Amanda R, et al.
Publicado: (2003)

Cannot write session to /tmp/vufind_sessions/sess_hfj9hlnldjscpbstql4914ajcc