Selective serotonin reuptake inhibitor, fluoxetine, impairs E-cadherin-mediated cell adhesion and alters calcium homeostasis in pancreatic beta cells

Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed drugs for mood disorders. Long term use of SSRIs is associated with an increased risk of diabetes, but the underlying mechanism(s) remains elusive. E-cadherin-mediated cell-cell adhesion and elevated [Ca(2+)](i) are imp...

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Detalles Bibliográficos
Autores principales: Chang, Huang-Yu, Chen, Shu-Ling, Shen, Meng-Ru, Kung, Mei-Lang, Chuang, Lee-Ming, Chen, Yun-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471211/
https://www.ncbi.nlm.nih.gov/pubmed/28615694
http://dx.doi.org/10.1038/s41598-017-03747-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471211/
https://www.ncbi.nlm.nih.gov/pubmed/28615694
http://dx.doi.org/10.1038/s41598-017-03747-0

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