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Improving the detection of pathways in genome-wide association studies by combined effects of SNPs from Linkage Disequilibrium blocks
Genome-wide association studies (GWAS) have successfully identified single variants associated with diseases. To increase the power of GWAS, gene-based and pathway-based tests are commonly employed to detect more risk factors. However, the gene- and pathway-based association tests may be biased towa...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471232/ https://www.ncbi.nlm.nih.gov/pubmed/28615668 http://dx.doi.org/10.1038/s41598-017-03826-2 |