Neuronal P2X7 receptor-induced reactive oxygen species production contributes to nociceptive behavior in mice

ATP can activate a variety of pathways through P2 purinoreceptors, leading to neuroprotection and pathology in the CNS. Among all P2X receptors, the P2X7 receptor (P2X7R) is a well-defined therapeutic target for inflammatory and neuropathic pain. Activation of P2X7R can generate reactive oxygen spec...

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Detalles Bibliográficos
Autores principales: Munoz, Frances M., Gao, Ruby, Tian, Yuzhen, Henstenburg, Brian A., Barrett, James E., Hu, Huijuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471238/
https://www.ncbi.nlm.nih.gov/pubmed/28615626
http://dx.doi.org/10.1038/s41598-017-03813-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471238/
https://www.ncbi.nlm.nih.gov/pubmed/28615626
http://dx.doi.org/10.1038/s41598-017-03813-7

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