Differential depression of neuronal network activity by midazolam and its main metabolite 1-hydroxymidazolam in cultured neocortical slices

The benzodiazepine midazolam is widely used in critical care medicine. Midazolam has a clinically active metabolite, 1-hydroxymidazolam. The contribution of 1-hydroxymidazolam to the effects of midazolam is controversial. The aim of the current study was to compare the actions of midazolam and 1-hyd...

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Detalles Bibliográficos
Autores principales: Balk, Monika, Hentschke, Harald, Rudolph, Uwe, Antkowiak, Bernd, Drexler, Berthold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471240/
https://www.ncbi.nlm.nih.gov/pubmed/28615640
http://dx.doi.org/10.1038/s41598-017-03154-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471240/
https://www.ncbi.nlm.nih.gov/pubmed/28615640
http://dx.doi.org/10.1038/s41598-017-03154-5

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