Anti-leukemia activity of a Hsp70 inhibitor and its hybrid molecules

In this study we examined the anti-leukemia activity of a small molecule inhibitor of Hsp70 proteins, apoptozole (Az), and hybrids in which it is linked to an inhibitor of either Hsp90 (geldanamycin) or Abl kinase (imatinib). The results of NMR studies revealed that Az associates with an ATPase doma...

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Detalles Bibliográficos
Autores principales: Park, Seong-Hyun, Kim, Won-Je, Li, Hui, Seo, Wonil, Park, Sang-Hyun, Kim, Hwan, Shin, Sang Chul, Zuiderweg, Erik R. P., Kim, Eunice EunKyeong, Sim, Taebo, Kim, Nak-Kyoon, Shin, Injae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471252/
https://www.ncbi.nlm.nih.gov/pubmed/28615625
http://dx.doi.org/10.1038/s41598-017-03814-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471252/
https://www.ncbi.nlm.nih.gov/pubmed/28615625
http://dx.doi.org/10.1038/s41598-017-03814-6

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