An alternative conformation of ERβ bound to estradiol reveals H12 in a stable antagonist position

The natural ligand 17β-estradiol (E2) is so far believed to induce a unique agonist-bound active conformation in the ligand binding domain (LBD) of the estrogen receptors (ERs). Both subtypes, ERα and ERβ, are transcriptionally activated in the presence of E2 with ERβ being somewhat less active than...

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Detalles Bibliográficos
Autores principales: Souza, Paulo C. T., Textor, Larissa C., Melo, Denise C., Nascimento, Alessandro S., Skaf, Munir S., Polikarpov, Igor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471280/
https://www.ncbi.nlm.nih.gov/pubmed/28615710
http://dx.doi.org/10.1038/s41598-017-03774-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471280/
https://www.ncbi.nlm.nih.gov/pubmed/28615710
http://dx.doi.org/10.1038/s41598-017-03774-x

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