Linaclotide activates guanylate cyclase‐C/cGMP/protein kinase‐II‐dependent trafficking of CFTR in the intestine

The transmembrane receptor guanylyl cyclase‐C (GC‐C), expressed on enterocytes along the intestine, is the molecular target of the GC‐C agonist peptide linaclotide, an FDA‐approved drug for treatment of adult patients with Irritable Bowel Syndrome with Constipation and Chronic Idiopathic Constipatio...

Descripción completa

Detalles Bibliográficos
Autores principales: Ahsan, Md. Kaimul, Tchernychev, Boris, Kessler, Marco M., Solinga, Robert M., Arthur, David, Linde, Cristina I., Silos‐Santiago, Inmaculada, Hannig, Gerhard, Ameen, Nadia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471438/
https://www.ncbi.nlm.nih.gov/pubmed/28592587
http://dx.doi.org/10.14814/phy2.13299

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471438/
https://www.ncbi.nlm.nih.gov/pubmed/28592587
http://dx.doi.org/10.14814/phy2.13299

Ejemplares similares