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Structural Probing and Molecular Modeling of the A(3) Adenosine Receptor: A Focus on Agonist Binding

Adenosine is an endogenous modulator exerting its functions through the activation of four adenosine receptor (AR) subtypes, termed A(1), A(2A), A(2B) and A(3), which belong to the G protein-coupled receptor (GPCR) superfamily. The human A(3)AR (hA(3)AR) subtype is implicated in several cytoprotecti...

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Detalles Bibliográficos
Autores principales: Ciancetta, Antonella, Jacobson, Kenneth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471610/
https://www.ncbi.nlm.nih.gov/pubmed/28287473
http://dx.doi.org/10.3390/molecules22030449