Hyperglucagonemia in an animal model of insulin- deficient diabetes: what therapy can improve it?

BACKGROUND: Intra-islet insulin contributes to alpha-cell suppression. Akita mice carry a toxic-gain-of- function Ins2 gene mutation encoding proinsulin-C(A7)Y, similar to that described in human Mutant Ins-gene induced Diabetes of Youth, which decreases intra-islet insulin. Herein, we examined Akit...

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Detalles Bibliográficos
Autores principales: Barbetti, Fabrizio, Colombo, Carlo, Haataja, Leena, Cras-Méneur, Corentin, Bernardini, Sergio, Arvan, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471666/
https://www.ncbi.nlm.nih.gov/pubmed/28702245
http://dx.doi.org/10.1186/s40842-016-0029-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471666/
https://www.ncbi.nlm.nih.gov/pubmed/28702245
http://dx.doi.org/10.1186/s40842-016-0029-5

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