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Hyperglucagonemia in an animal model of insulin- deficient diabetes: what therapy can improve it?
BACKGROUND: Intra-islet insulin contributes to alpha-cell suppression. Akita mice carry a toxic-gain-of- function Ins2 gene mutation encoding proinsulin-C(A7)Y, similar to that described in human Mutant Ins-gene induced Diabetes of Youth, which decreases intra-islet insulin. Herein, we examined Akit...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471666/ https://www.ncbi.nlm.nih.gov/pubmed/28702245 http://dx.doi.org/10.1186/s40842-016-0029-5 |