Stereocontrolled semi-syntheses of deguelin and tephrosin

We describe stereocontrolled semi-syntheses of deguelin and tephrosin, anti-cancer rotenoids isolated from Tephrosia vogelii. Firstly, we present a new two-step transformation of rotenone into rot-2′-enonic acid via a zinc-mediated ring opening of rotenone hydrobromide. Secondly, following conversio...

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Detalles Bibliográficos
Autores principales: Russell, David A., Freudenreich, Julien J., Ciardiello, Joe J., Sore, Hannah F., Spring, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471929/
https://www.ncbi.nlm.nih.gov/pubmed/28134391
http://dx.doi.org/10.1039/c6ob02659a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471929/
https://www.ncbi.nlm.nih.gov/pubmed/28134391
http://dx.doi.org/10.1039/c6ob02659a

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