The role of cullin4B in human cancers

Cullin 4B (CUL4B) is a scaffold of the Cullin4B-Ring E3 ligase complex (CRL4B) that plays an important role in proteolysis and is implicated in tumorigenesis. Aberrant expression of CUL4B has been reported in various types of human diseases. Recently, studies have shown that CUL4B was overexpressed...

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Detalles Bibliográficos
Autores principales: Li, Ying, Wang, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471934/
https://www.ncbi.nlm.nih.gov/pubmed/28630798
http://dx.doi.org/10.1186/s40164-017-0077-2
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author Li, Ying
Wang, Xin
author_facet Li, Ying
Wang, Xin
author_sort Li, Ying
collection PubMed
description Cullin 4B (CUL4B) is a scaffold of the Cullin4B-Ring E3 ligase complex (CRL4B) that plays an important role in proteolysis and is implicated in tumorigenesis. Aberrant expression of CUL4B has been reported in various types of human diseases. Recently, studies have shown that CUL4B was overexpressed in a multitude of solid neoplasms and affect the expression of several tumor suppressor genes. In this review, we aim to summarize the biological function of CUL4B in order to better understand its pathogenesis in human cancers.
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spelling pubmed-54719342017-06-19 The role of cullin4B in human cancers Li, Ying Wang, Xin Exp Hematol Oncol Review Cullin 4B (CUL4B) is a scaffold of the Cullin4B-Ring E3 ligase complex (CRL4B) that plays an important role in proteolysis and is implicated in tumorigenesis. Aberrant expression of CUL4B has been reported in various types of human diseases. Recently, studies have shown that CUL4B was overexpressed in a multitude of solid neoplasms and affect the expression of several tumor suppressor genes. In this review, we aim to summarize the biological function of CUL4B in order to better understand its pathogenesis in human cancers. BioMed Central 2017-06-15 /pmc/articles/PMC5471934/ /pubmed/28630798 http://dx.doi.org/10.1186/s40164-017-0077-2 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Li, Ying
Wang, Xin
The role of cullin4B in human cancers
title The role of cullin4B in human cancers
title_full The role of cullin4B in human cancers
title_fullStr The role of cullin4B in human cancers
title_full_unstemmed The role of cullin4B in human cancers
title_short The role of cullin4B in human cancers
title_sort role of cullin4b in human cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471934/
https://www.ncbi.nlm.nih.gov/pubmed/28630798
http://dx.doi.org/10.1186/s40164-017-0077-2
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