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Chemokine receptor co-expression reveals aberrantly distributed T(H) effector memory cells in GPA patients

BACKGROUND: Persistent expansion of circulating CD4(+) effector memory T cells (T(EM)) in patients with granulomatosis with polyangiitis (GPA) suggests their fundamental role in disease pathogenesis. Recent studies have shown that distinct functional CD4(+) T(EM) cell subsets can be identified based...

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Detalles Bibliográficos
Autores principales: Lintermans, Lucas L., Rutgers, Abraham, Stegeman, Coen A., Heeringa, Peter, Abdulahad, Wayel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471953/
https://www.ncbi.nlm.nih.gov/pubmed/28615072
http://dx.doi.org/10.1186/s13075-017-1343-8