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A novel application of the Staudinger ligation to access neutral cyclic di-nucleotide analog precursors via a divergent method

Our efforts to develop a scalable and divergent synthesis of cyclic di-nucleotide analog precursors have resulted in (1) an orthogonally protected di-amino carbohydrate as well as (2) the novel application of the Staudinger ligation to provide medium-sized macrocycles featuring carbamate or urea lin...

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Detalles Bibliográficos
Autores principales: Fletcher, M. H., Burns-Lynch, C. E., Knouse, K. W., Abraham, L. T., DeBrosse, C. W., Wuest, W. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472050/
https://www.ncbi.nlm.nih.gov/pubmed/28670448
http://dx.doi.org/10.1039/c7ra06045a