A novel application of the Staudinger ligation to access neutral cyclic di-nucleotide analog precursors via a divergent method

Our efforts to develop a scalable and divergent synthesis of cyclic di-nucleotide analog precursors have resulted in (1) an orthogonally protected di-amino carbohydrate as well as (2) the novel application of the Staudinger ligation to provide medium-sized macrocycles featuring carbamate or urea lin...

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Detalles Bibliográficos
Autores principales: Fletcher, M. H., Burns-Lynch, C. E., Knouse, K. W., Abraham, L. T., DeBrosse, C. W., Wuest, W. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472050/
https://www.ncbi.nlm.nih.gov/pubmed/28670448
http://dx.doi.org/10.1039/c7ra06045a
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author Fletcher, M. H.
Burns-Lynch, C. E.
Knouse, K. W.
Abraham, L. T.
DeBrosse, C. W.
Wuest, W. M.
author_facet Fletcher, M. H.
Burns-Lynch, C. E.
Knouse, K. W.
Abraham, L. T.
DeBrosse, C. W.
Wuest, W. M.
author_sort Fletcher, M. H.
collection PubMed
description Our efforts to develop a scalable and divergent synthesis of cyclic di-nucleotide analog precursors have resulted in (1) an orthogonally protected di-amino carbohydrate as well as (2) the novel application of the Staudinger ligation to provide medium-sized macrocycles featuring carbamate or urea linkages.
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spelling pubmed-54720502017-06-28 A novel application of the Staudinger ligation to access neutral cyclic di-nucleotide analog precursors via a divergent method Fletcher, M. H. Burns-Lynch, C. E. Knouse, K. W. Abraham, L. T. DeBrosse, C. W. Wuest, W. M. RSC Adv Chemistry Our efforts to develop a scalable and divergent synthesis of cyclic di-nucleotide analog precursors have resulted in (1) an orthogonally protected di-amino carbohydrate as well as (2) the novel application of the Staudinger ligation to provide medium-sized macrocycles featuring carbamate or urea linkages. Royal Society of Chemistry 2017-06-07 2017-06-07 /pmc/articles/PMC5472050/ /pubmed/28670448 http://dx.doi.org/10.1039/c7ra06045a Text en This journal is © The Royal Society of Chemistry 2017 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Fletcher, M. H.
Burns-Lynch, C. E.
Knouse, K. W.
Abraham, L. T.
DeBrosse, C. W.
Wuest, W. M.
A novel application of the Staudinger ligation to access neutral cyclic di-nucleotide analog precursors via a divergent method
title A novel application of the Staudinger ligation to access neutral cyclic di-nucleotide analog precursors via a divergent method
title_full A novel application of the Staudinger ligation to access neutral cyclic di-nucleotide analog precursors via a divergent method
title_fullStr A novel application of the Staudinger ligation to access neutral cyclic di-nucleotide analog precursors via a divergent method
title_full_unstemmed A novel application of the Staudinger ligation to access neutral cyclic di-nucleotide analog precursors via a divergent method
title_short A novel application of the Staudinger ligation to access neutral cyclic di-nucleotide analog precursors via a divergent method
title_sort novel application of the staudinger ligation to access neutral cyclic di-nucleotide analog precursors via a divergent method
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472050/
https://www.ncbi.nlm.nih.gov/pubmed/28670448
http://dx.doi.org/10.1039/c7ra06045a
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