Time-programmable drug dosing allows the manipulation, suppression and reversal of antibiotic drug resistance in vitro

Multi-drug strategies have been attempted to prolong the efficacy of existing antibiotics, but with limited success. Here we show that the evolution of multi-drug-resistant Escherichia coli can be manipulated in vitro by administering pairs of antibiotics and switching between them in ON/OFF manner....

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Detalles Bibliográficos
Autores principales: Yoshida, Mari, Reyes, Sabrina Galiñanes, Tsuda, Soichiro, Horinouchi, Takaaki, Furusawa, Chikara, Cronin, Leroy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472167/
https://www.ncbi.nlm.nih.gov/pubmed/28593940
http://dx.doi.org/10.1038/ncomms15589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472167/
https://www.ncbi.nlm.nih.gov/pubmed/28593940
http://dx.doi.org/10.1038/ncomms15589

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