Preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information

Matrix metalloproteinases (MMPs) contribute to the breakdown of tissue structures such as the basement membrane, promoting tissue fibrosis. Here we developed an electrospun membrane biofunctionalized with a fragment of the laminin β1-chain to modulate the expression of MMP2 in this context. We demon...

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Detalles Bibliográficos
Autores principales: Horejs, Christine-Maria, St-Pierre, Jean-Philippe, Ojala, Juha R. M., Steele, Joseph A. M., da Silva, Patricia Barros, Rynne-Vidal, Angela, Maynard, Stephanie A., Hansel, Catherine S., Rodríguez-Fernández, Clara, Mazo, Manuel M., You, Amanda Y. F., Wang, Alex J., von Erlach, Thomas, Tryggvason, Karl, López-Cabrera, Manuel, Stevens, Molly M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472175/
https://www.ncbi.nlm.nih.gov/pubmed/28593951
http://dx.doi.org/10.1038/ncomms15509

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472175/
https://www.ncbi.nlm.nih.gov/pubmed/28593951
http://dx.doi.org/10.1038/ncomms15509

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