Drug Binding Poses Relate Structure with Efficacy in the μ Opioid Receptor

The μ-opioid receptor (MOPr) is a clinically important G protein-coupled receptor that couples to G(i/o) proteins and arrestins. At present, the receptor conformational changes that occur following agonist binding and activation are poorly understood. This study has employed molecular dynamics simul...

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Detalles Bibliográficos
Autores principales: Sutcliffe, Katy J., Henderson, Graeme, Kelly, Eamonn, Sessions, Richard B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472181/
https://www.ncbi.nlm.nih.gov/pubmed/28502792
http://dx.doi.org/10.1016/j.jmb.2017.05.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472181/
https://www.ncbi.nlm.nih.gov/pubmed/28502792
http://dx.doi.org/10.1016/j.jmb.2017.05.009

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