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Drug Binding Poses Relate Structure with Efficacy in the μ Opioid Receptor
The μ-opioid receptor (MOPr) is a clinically important G protein-coupled receptor that couples to G(i/o) proteins and arrestins. At present, the receptor conformational changes that occur following agonist binding and activation are poorly understood. This study has employed molecular dynamics simul...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472181/ https://www.ncbi.nlm.nih.gov/pubmed/28502792 http://dx.doi.org/10.1016/j.jmb.2017.05.009 |