Human CTP synthase filament structure reveals the active enzyme conformation

The universally conserved enzyme CTP synthase (CTPS) forms filaments in bacteria and eukaryotes. In bacteria polymerization inhibits CTPS activity and is required for nucleotide homeostasis. Here we show that human CTPS polymerization increases catalytic activity. The cryoEM structures of bacterial...

Descripción completa

Detalles Bibliográficos
Autores principales: Lynch, Eric M., Hicks, Derrick R., Shepherd, Matthew, Endrizzi, James A., Maker, Allison, Hansen, Jesse M., Barry, Rachael M., Gitai, Zemer, Baldwin, Enoch P., Kollman, Justin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472220/
https://www.ncbi.nlm.nih.gov/pubmed/28459447
http://dx.doi.org/10.1038/nsmb.3407

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472220/
https://www.ncbi.nlm.nih.gov/pubmed/28459447
http://dx.doi.org/10.1038/nsmb.3407

Ejemplares similares