Severity classification of repeated isoflurane anesthesia in C57BL/6JRj mice—Assessing the degree of distress

According to the EU Directive 2010/63, the severity of a procedure has to be classified as mild, moderate or severe. General anesthesia is thought to be mild, but the Directive does not differentiate between single and repeated anesthesia. Therefore, we investigated the impact of repeated administra...

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Detalles Bibliográficos
Autores principales: Hohlbaum, Katharina, Bert, Bettina, Dietze, Silke, Palme, Rupert, Fink, Heidrun, Thöne-Reineke, Christa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472303/
https://www.ncbi.nlm.nih.gov/pubmed/28617851
http://dx.doi.org/10.1371/journal.pone.0179588

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472303/
https://www.ncbi.nlm.nih.gov/pubmed/28617851
http://dx.doi.org/10.1371/journal.pone.0179588

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