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Severity classification of repeated isoflurane anesthesia in C57BL/6JRj mice—Assessing the degree of distress
According to the EU Directive 2010/63, the severity of a procedure has to be classified as mild, moderate or severe. General anesthesia is thought to be mild, but the Directive does not differentiate between single and repeated anesthesia. Therefore, we investigated the impact of repeated administra...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472303/ https://www.ncbi.nlm.nih.gov/pubmed/28617851 http://dx.doi.org/10.1371/journal.pone.0179588 |