Analysis of DNA polymerase ν function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance

DNA polymerase ν (pol ν), encoded by the POLN gene, is an A-family DNA polymerase in vertebrates and some other animal lineages. Here we report an in-depth analysis of pol ν–defective mice and human cells. POLN is very weakly expressed in most tissues, with the highest relative expression in testis....

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Detalles Bibliográficos
Autores principales: Takata, Kei-ichi, Reh, Shelley, Yousefzadeh, Matthew J., Zelazowski, Maciej J., Bhetawal, Sarita, Trono, David, Lowery, Megan G., Sandoval, Maria, Takata, Yoko, Lu, Yue, Lin, Kevin, Shen, Jianjun, Kusewitt, Donna F., McBride, Kevin M., Cole, Francesca, Wood, Richard D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472330/
https://www.ncbi.nlm.nih.gov/pubmed/28570559
http://dx.doi.org/10.1371/journal.pgen.1006818

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472330/
https://www.ncbi.nlm.nih.gov/pubmed/28570559
http://dx.doi.org/10.1371/journal.pgen.1006818

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