Asymmetric recognition of HIV-1 Envelope trimer by V1V2 loop-targeting antibodies

The HIV-1 envelope (Env) glycoprotein binds to host cell receptors to mediate membrane fusion. The prefusion Env trimer is stabilized by V1V2 loops that interact at the trimer apex. Broadly neutralizing antibodies (bNAbs) against V1V2 loops, exemplified by PG9, bind asymmetrically as a single Fab to...

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Detalles Bibliográficos
Autores principales: Wang, Haoqing, Gristick, Harry B, Scharf, Louise, West, Anthony P, Galimidi, Rachel P, Seaman, Michael S, Freund, Natalia T, Nussenzweig, Michel C, Bjorkman, Pamela J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472438/
https://www.ncbi.nlm.nih.gov/pubmed/28548638
http://dx.doi.org/10.7554/eLife.27389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472438/
https://www.ncbi.nlm.nih.gov/pubmed/28548638
http://dx.doi.org/10.7554/eLife.27389

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