Cargando…
Substrate transport and anion permeation proceed through distinct pathways in glutamate transporters
Advances in structure-function analyses and computational biology have enabled a deeper understanding of how excitatory amino acid transporters (EAATs) mediate chloride permeation and substrate transport. However, the mechanism of structural coupling between these functions remains to be established...
Autores principales: | Cheng, Mary Hongying, Torres-Salazar, Delany, Gonzalez-Suarez, Aneysis D, Amara, Susan G, Bahar, Ivet |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472439/ https://www.ncbi.nlm.nih.gov/pubmed/28569666 http://dx.doi.org/10.7554/eLife.25850 |
Ejemplares similares
-
Glial and Neuronal Glutamate Transporters Differ in the Na(+) Requirements for Activation of the Substrate-Independent Anion Conductance
por: Divito, Christopher B., et al.
Publicado: (2017) -
Time-resolved Mechanism of Extracellular Gate Opening and Substrate
Binding in a Glutamate
Transporter
por: Shrivastava, Indira H., et al.
Publicado: (2008) -
Coupled ion binding and structural transitions along the transport cycle of glutamate transporters
por: Verdon, Grégory, et al.
Publicado: (2014) -
Large domain movements through the lipid bilayer mediate substrate release and inhibition of glutamate transporters
por: Wang, Xiaoyu, et al.
Publicado: (2020) -
Mechanism of substrate binding and transport in BASS transporters
por: Becker, Patrick, et al.
Publicado: (2023)