Cargando…

Improved Gene Delivery to Adult Mouse Spinal Cord Through the Use of Engineered Hybrid Adeno-Associated Viral serotypes

Adeno-associated viral (AAV) vectors are often used in gene therapy for neurological disorders because of its safety profile and promising results in clinical trials. One challenge to AAV gene therapy is effective transduction of large numbers of the appropriate cell type, which can be overcome by m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Siu, Jason J., Queen, Nicholas J., Huang, Wei, Yin, Feng Qin, Liu, Xianglan, McTigue, Dana M., Cao, Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472488/ https://www.ncbi.nlm.nih.gov/pubmed/28440798 http://dx.doi.org/10.1038/gt.2017.27

Ejemplares similares

Potential Therapeutic Targets for PPARγ after Spinal Cord Injury
por: McTigue, Dana M.
Publicado: (2008)

The fate of proliferating cells in the injured adult spinal cord
por: McTigue, Dana M, et al.
Publicado: (2011)

Delayed short-term tamoxifen treatment does not promote remyelination or neuron sparing after spinal cord injury
por: Pukos, Nicole, et al.
Publicado: (2020)

Alpha-synuclein increases in rodent and human spinal cord injury and promotes inflammation and tissue loss
por: Sauerbeck, Andrew D., et al.
Publicado: (2021)

Axonal transport of adeno-associated viral vectors is serotype-dependent
por: Salegio, Ernesto A., et al.
Publicado: (2012)

MR-guided parenchymal delivery of adeno-associated viral vector serotype 5 in non-human primate brain
por: Samaranch, L, et al.
Publicado: (2017)

Adeno-Associated Viral Vectors Serotype 8 for Cell-Specific Delivery of Therapeutic Genes in the Central Nervous System
por: Pignataro, Diego, et al.
Publicado: (2017)

Targeting Visceral Fat by Intraperitoneal Delivery of Novel AAV Serotype Vector Restricting Off-Target Transduction in Liver
por: Huang, Wei, et al.
Publicado: (2017)

Infectivity of adeno-associated virus serotypes in mouse testis
por: Rajasekaran, Santhanasabapathy, et al.
Publicado: (2018)

Intraspinal injection of adeno-associated viruses into the adult mouse spinal cord
por: Chaterji, Shrivas, et al.
Publicado: (2021)

Adeno-associated viral delivery of engineered tRNA-enzyme pairs into nonsense mutation mouse models
por: Zheng, Zhetao, et al.
Publicado: (2022)

Adeno-Associated Viral Vector Serotype 5 Poorly Transduces Liver in Rat Models
por: Montenegro-Miranda, Paula S., et al.
Publicado: (2013)

Inhibition of astroglial NF-kappaB enhances oligodendrogenesis following spinal cord injury
por: Bracchi-Ricard, Valerie, et al.
Publicado: (2013)

Recombinant Adeno-Associated Virus Serotype 9 Gene Therapy in Spinal Muscular Atrophy
por: Kotulska, Katarzyna, et al.
Publicado: (2021)

Biodistribution of adeno-associated virus serotype 9 (AAV9) vector after intrathecal and intravenous delivery in mouse
por: Schuster, Daniel J., et al.
Publicado: (2014)

Transduction characteristics of alternative adeno-associated virus serotypes in the cat brain by intracisternal delivery
por: Hunter, Jacqueline E., et al.
Publicado: (2022)

Recombinant Vectors Based on Porcine Adeno-Associated Viral Serotypes Transduce the Murine and Pig Retina
por: Puppo, Agostina, et al.
Publicado: (2013)

Correction: Adeno-Associated Viral Vector Serotype 5 Poorly Transduces Liver in Rat Models
Publicado: (2014)

Correction: Adeno-Associated Viral Vector Serotype 5 Poorly Transduces Liver in Rat Models
Publicado: (2015)

Toxicity and Biodistribution of the Serotype 2 Recombinant Adeno-Associated Viral Vector, Encoding Aquaporin-1, after Retroductal Delivery to a Single Mouse Parotid Gland
por: Momot, Dariya, et al.
Publicado: (2014)

Sub-cellular In-situ Characterization of Ferritin(iron) in a Rodent Model of Spinal Cord Injury
por: Blissett, A. R., et al.
Publicado: (2018)

Adeno-associated virus serotype rh.10 displays strong muscle tropism following intraperitoneal delivery
por: Ai, Jianzhong, et al.
Publicado: (2017)

AAVR-Displaying Interfaces: Serotype-Independent Adeno-Associated Virus Capture and Local Delivery Systems
por: Kim, Seung-Hyun, et al.
Publicado: (2019)

Reduced Immunogenicity of Intraparenchymal Delivery of Adeno-Associated Virus Serotype 2 Vectors: Brief Overview
por: Hwu, Wuh-Liang, et al.
Publicado: (2022)

Adeno-associated virus serotype 9 antibody seroprevalence for patients in the United States with spinal muscular atrophy
por: Day, John W., et al.
Publicado: (2023)

Designer Gene Delivery Vectors: Molecular Engineering and Evolution of Adeno-Associated Viral Vectors for Enhanced Gene Transfer
por: Kwon, Inchan, et al.
Publicado: (2007)

Adeno-associated virus serotype 9 efficiently targets ischemic skeletal muscle following systemic delivery
por: Katwal, Arabindra B., et al.
Publicado: (2013)

Targeted Gene Delivery into the Mammalian Inner Ear Using Synthetic Serotypes of Adeno-Associated Virus Vectors
por: Kim, Min-A, et al.
Publicado: (2019)

A toolbox of astrocyte-specific, serotype-independent adeno-associated viral vectors using microRNA targeting sequences
por: Gleichman, Amy J., et al.
Publicado: (2023)

Adeno-associated viral vector serotype 9-based gene replacement therapy for SURF1-related Leigh syndrome
por: Ling, Qinglan, et al.
Publicado: (2021)

Microglia coordinate cellular interactions during spinal cord repair in mice
por: Brennan, Faith H., et al.
Publicado: (2022)

Perinatal systemic gene delivery using adeno-associated viral vectors
por: Karda, Rajvinder, et al.
Publicado: (2014)

Adeno-Associated Viral Vectors Show Serotype Specific Transduction of Equine Joint Tissue Explants and Cultured Monolayers
por: Hemphill, Daniel D., et al.
Publicado: (2014)

Supraspinal gene transfer by intrathecal adeno-associated virus serotype 5
por: Schuster, Daniel J., et al.
Publicado: (2014)

Adeno-associated viral serotypes produce differing titers and differentially transduce neurons within the rat basal and lateral amygdala
por: Holehonnur, Roopashri, et al.
Publicado: (2014)

Transduction of rat and human adipose-tissue derived mesenchymal stromal cells by adeno-associated viral vector serotype DJ
por: Zubkova, Ekaterina S., et al.
Publicado: (2021)

Adeno-Associated Viral Vectors as a Tool for Large Gene Delivery to the Retina
por: Trapani, Ivana
Publicado: (2019)

In vivo mitochondrial base editing via adeno-associated viral delivery to mouse post-mitotic tissue
por: Silva-Pinheiro, Pedro, et al.
Publicado: (2022)

In utero intracerebroventricular delivery of adeno-associated viral vectors to target mouse choroid plexus and cerebrospinal fluid
por: Jang, Ahram, et al.
Publicado: (2022)

Systemic Delivery of MicroRNA Using Recombinant Adeno-associated Virus Serotype 9 to Treat Neuromuscular Diseases in Rodents
por: Pourshafie, Naemeh, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_vvo4vpagd2ncshjftpbn4a8d3p