The protein kinase MBK-1 contributes to lifespan extension in daf-2 mutant and germline-deficient Caenorhabditis elegans

In Caenorhabditis elegans, reduction of insulin/IGF-1 like signaling and loss of germline stem cells both increase lifespan by activating the conserved transcription factor DAF-16 (FOXO). While the mechanisms that regulate DAF-16 nuclear localization in response to insulin/IGF-1 like signaling are w...

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Detalles Bibliográficos
Autores principales: Mack, Hildegard I. D., Zhang, Peichuan, Fonslow, Bryan R., Yates, John R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472741/
https://www.ncbi.nlm.nih.gov/pubmed/28562327
http://dx.doi.org/10.18632/aging.101244

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472741/
https://www.ncbi.nlm.nih.gov/pubmed/28562327
http://dx.doi.org/10.18632/aging.101244

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