A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action

The prolyl isomerase PIN1, a critical modifier of multiple signalling pathways, is overexpressed in the majority of cancers and its activity strongly contributes to tumour initiation and progression. Inactivation of PIN1 function conversely curbs tumour growth and cancer stem cell expansion, restore...

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Detalles Bibliográficos
Autores principales: Campaner, Elena, Rustighi, Alessandra, Zannini, Alessandro, Cristiani, Alberto, Piazza, Silvano, Ciani, Yari, Kalid, Ori, Golan, Gali, Baloglu, Erkan, Shacham, Sharon, Valsasina, Barbara, Cucchi, Ulisse, Pippione, Agnese Chiara, Lolli, Marco Lucio, Giabbai, Barbara, Storici, Paola, Carloni, Paolo, Rossetti, Giulia, Benvenuti, Federica, Bello, Ezia, D'Incalci, Maurizio, Cappuzzello, Elisa, Rosato, Antonio, Del Sal, Giannino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472749/
https://www.ncbi.nlm.nih.gov/pubmed/28598431
http://dx.doi.org/10.1038/ncomms15772

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472749/
https://www.ncbi.nlm.nih.gov/pubmed/28598431
http://dx.doi.org/10.1038/ncomms15772

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