DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity

Radiotherapy is under investigation for its ability to enhance responses to immunotherapy. However, the mechanisms by which radiation induces anti-tumour T cells remain unclear. We show that the DNA exonuclease Trex1 is induced by radiation doses above 12–18 Gy in different cancer cells, and attenua...

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Detalles Bibliográficos
Autores principales: Vanpouille-Box, Claire, Alard, Amandine, Aryankalayil, Molykutty J., Sarfraz, Yasmeen, Diamond, Julie M., Schneider, Robert J., Inghirami, Giorgio, Coleman, C. Norman, Formenti, Silvia C., Demaria, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472757/
https://www.ncbi.nlm.nih.gov/pubmed/28598415
http://dx.doi.org/10.1038/ncomms15618

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472757/
https://www.ncbi.nlm.nih.gov/pubmed/28598415
http://dx.doi.org/10.1038/ncomms15618

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