MYC activation cooperates with Vhl and Ink4a/Arf loss to induce clear cell renal cell carcinoma

Renal carcinoma is a common and aggressive malignancy whose histopathogenesis is incompletely understood and that is largely resistant to cytotoxic chemotherapy. We present two mouse models of kidney cancer that recapitulate the genomic alterations found in human papillary (pRCC) and clear cell RCC...

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Detalles Bibliográficos
Autores principales: Bailey, Sean T., Smith, Aleisha M., Kardos, Jordan, Wobker, Sara E., Wilson, Harper L., Krishnan, Bhavani, Saito, Ryoichi, Lee, Hyo Jin, Zhang, Jing, Eaton, Samuel C., Williams, Lindsay A., Manocha, Ujjawal, Peters, Dorien J., Pan, Xinchao, Carroll, Thomas J., Felsher, Dean W., Walter, Vonn, Zhang, Qing, Parker, Joel S., Yeh, Jen Jen, Moffitt, Richard A., Leung, Janet Y., Kim, William Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472759/
https://www.ncbi.nlm.nih.gov/pubmed/28593993
http://dx.doi.org/10.1038/ncomms15770

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472759/
https://www.ncbi.nlm.nih.gov/pubmed/28593993
http://dx.doi.org/10.1038/ncomms15770

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