Paget's Disease: Skeletal Manifestations and Effect of Bisphosphonates

BACKGROUND: Paget's disease of bone leads to change in the shape and size of the bone and results in reduced bone strength, leading to the complications of deformity, arthritis, and fracture. Due to unknown reasons, Paget's disease is rare in Asian descendants. We report the cases of Paget...

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Autores principales: Kang, Ho, Park, Young-Chang, Yang, Kyu Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Bone and Mineral Research 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472804/
https://www.ncbi.nlm.nih.gov/pubmed/28642853
http://dx.doi.org/10.11005/jbm.2017.24.2.97
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author Kang, Ho
Park, Young-Chang
Yang, Kyu Hyun
author_facet Kang, Ho
Park, Young-Chang
Yang, Kyu Hyun
author_sort Kang, Ho
collection PubMed
description BACKGROUND: Paget's disease of bone leads to change in the shape and size of the bone and results in reduced bone strength, leading to the complications of deformity, arthritis, and fracture. Due to unknown reasons, Paget's disease is rare in Asian descendants. We report the cases of Paget's disease who visited our institute for 15 years and reviewed the literatures. METHODS: We retrospectively reviewed the medical records and radiograms of 8 patients (6 female and 2 male) who were diagnosed as Paget's disease of bone. Diagnosis was confirmed by typical radiological feature in the involved skeletons and/or pathologic findings. RESULTS: Pelvis, skull and spine were three most frequently involved bones. All involved bones in our cases showed changes in shape and trabecular pattern which resulted in bowing of lower extremity, secondary osteoarthritis, compression fracture of spine and enlargement of skull. Mean follow time was 4.71 years and all patient were treated bisphosphonate (BP). Use of BP controlled the level of serum alkaline phosphatase level effectively. CONCLUSIONS: We have reviewed eight patients who were previously diagnosed as Paget's disease of bone in our institute. We could identify typical radiologic and clinical findings such as bowing deformity of long bone, secondary osteoarthritis, compression fracture and osteomyelitis of mandible that deteriorated the quality of their living.
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spelling pubmed-54728042017-06-22 Paget's Disease: Skeletal Manifestations and Effect of Bisphosphonates Kang, Ho Park, Young-Chang Yang, Kyu Hyun J Bone Metab Original Article BACKGROUND: Paget's disease of bone leads to change in the shape and size of the bone and results in reduced bone strength, leading to the complications of deformity, arthritis, and fracture. Due to unknown reasons, Paget's disease is rare in Asian descendants. We report the cases of Paget's disease who visited our institute for 15 years and reviewed the literatures. METHODS: We retrospectively reviewed the medical records and radiograms of 8 patients (6 female and 2 male) who were diagnosed as Paget's disease of bone. Diagnosis was confirmed by typical radiological feature in the involved skeletons and/or pathologic findings. RESULTS: Pelvis, skull and spine were three most frequently involved bones. All involved bones in our cases showed changes in shape and trabecular pattern which resulted in bowing of lower extremity, secondary osteoarthritis, compression fracture of spine and enlargement of skull. Mean follow time was 4.71 years and all patient were treated bisphosphonate (BP). Use of BP controlled the level of serum alkaline phosphatase level effectively. CONCLUSIONS: We have reviewed eight patients who were previously diagnosed as Paget's disease of bone in our institute. We could identify typical radiologic and clinical findings such as bowing deformity of long bone, secondary osteoarthritis, compression fracture and osteomyelitis of mandible that deteriorated the quality of their living. The Korean Society for Bone and Mineral Research 2017-05 2017-05-31 /pmc/articles/PMC5472804/ /pubmed/28642853 http://dx.doi.org/10.11005/jbm.2017.24.2.97 Text en Copyright © 2017 The Korean Society for Bone and Mineral Research http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kang, Ho
Park, Young-Chang
Yang, Kyu Hyun
Paget's Disease: Skeletal Manifestations and Effect of Bisphosphonates
title Paget's Disease: Skeletal Manifestations and Effect of Bisphosphonates
title_full Paget's Disease: Skeletal Manifestations and Effect of Bisphosphonates
title_fullStr Paget's Disease: Skeletal Manifestations and Effect of Bisphosphonates
title_full_unstemmed Paget's Disease: Skeletal Manifestations and Effect of Bisphosphonates
title_short Paget's Disease: Skeletal Manifestations and Effect of Bisphosphonates
title_sort paget's disease: skeletal manifestations and effect of bisphosphonates
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472804/
https://www.ncbi.nlm.nih.gov/pubmed/28642853
http://dx.doi.org/10.11005/jbm.2017.24.2.97
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