Paget's Disease: Skeletal Manifestations and Effect of Bisphosphonates
BACKGROUND: Paget's disease of bone leads to change in the shape and size of the bone and results in reduced bone strength, leading to the complications of deformity, arthritis, and fracture. Due to unknown reasons, Paget's disease is rare in Asian descendants. We report the cases of Paget...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Society for Bone and Mineral Research
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472804/ https://www.ncbi.nlm.nih.gov/pubmed/28642853 http://dx.doi.org/10.11005/jbm.2017.24.2.97 |
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author | Kang, Ho Park, Young-Chang Yang, Kyu Hyun |
author_facet | Kang, Ho Park, Young-Chang Yang, Kyu Hyun |
author_sort | Kang, Ho |
collection | PubMed |
description | BACKGROUND: Paget's disease of bone leads to change in the shape and size of the bone and results in reduced bone strength, leading to the complications of deformity, arthritis, and fracture. Due to unknown reasons, Paget's disease is rare in Asian descendants. We report the cases of Paget's disease who visited our institute for 15 years and reviewed the literatures. METHODS: We retrospectively reviewed the medical records and radiograms of 8 patients (6 female and 2 male) who were diagnosed as Paget's disease of bone. Diagnosis was confirmed by typical radiological feature in the involved skeletons and/or pathologic findings. RESULTS: Pelvis, skull and spine were three most frequently involved bones. All involved bones in our cases showed changes in shape and trabecular pattern which resulted in bowing of lower extremity, secondary osteoarthritis, compression fracture of spine and enlargement of skull. Mean follow time was 4.71 years and all patient were treated bisphosphonate (BP). Use of BP controlled the level of serum alkaline phosphatase level effectively. CONCLUSIONS: We have reviewed eight patients who were previously diagnosed as Paget's disease of bone in our institute. We could identify typical radiologic and clinical findings such as bowing deformity of long bone, secondary osteoarthritis, compression fracture and osteomyelitis of mandible that deteriorated the quality of their living. |
format | Online Article Text |
id | pubmed-5472804 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The Korean Society for Bone and Mineral Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-54728042017-06-22 Paget's Disease: Skeletal Manifestations and Effect of Bisphosphonates Kang, Ho Park, Young-Chang Yang, Kyu Hyun J Bone Metab Original Article BACKGROUND: Paget's disease of bone leads to change in the shape and size of the bone and results in reduced bone strength, leading to the complications of deformity, arthritis, and fracture. Due to unknown reasons, Paget's disease is rare in Asian descendants. We report the cases of Paget's disease who visited our institute for 15 years and reviewed the literatures. METHODS: We retrospectively reviewed the medical records and radiograms of 8 patients (6 female and 2 male) who were diagnosed as Paget's disease of bone. Diagnosis was confirmed by typical radiological feature in the involved skeletons and/or pathologic findings. RESULTS: Pelvis, skull and spine were three most frequently involved bones. All involved bones in our cases showed changes in shape and trabecular pattern which resulted in bowing of lower extremity, secondary osteoarthritis, compression fracture of spine and enlargement of skull. Mean follow time was 4.71 years and all patient were treated bisphosphonate (BP). Use of BP controlled the level of serum alkaline phosphatase level effectively. CONCLUSIONS: We have reviewed eight patients who were previously diagnosed as Paget's disease of bone in our institute. We could identify typical radiologic and clinical findings such as bowing deformity of long bone, secondary osteoarthritis, compression fracture and osteomyelitis of mandible that deteriorated the quality of their living. The Korean Society for Bone and Mineral Research 2017-05 2017-05-31 /pmc/articles/PMC5472804/ /pubmed/28642853 http://dx.doi.org/10.11005/jbm.2017.24.2.97 Text en Copyright © 2017 The Korean Society for Bone and Mineral Research http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kang, Ho Park, Young-Chang Yang, Kyu Hyun Paget's Disease: Skeletal Manifestations and Effect of Bisphosphonates |
title | Paget's Disease: Skeletal Manifestations and Effect of Bisphosphonates |
title_full | Paget's Disease: Skeletal Manifestations and Effect of Bisphosphonates |
title_fullStr | Paget's Disease: Skeletal Manifestations and Effect of Bisphosphonates |
title_full_unstemmed | Paget's Disease: Skeletal Manifestations and Effect of Bisphosphonates |
title_short | Paget's Disease: Skeletal Manifestations and Effect of Bisphosphonates |
title_sort | paget's disease: skeletal manifestations and effect of bisphosphonates |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472804/ https://www.ncbi.nlm.nih.gov/pubmed/28642853 http://dx.doi.org/10.11005/jbm.2017.24.2.97 |
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