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Non-inferiority versus superiority drug claims: the (not so) subtle distinction
BACKGROUND: Current regulatory guidance and practice of non-inferiority trials are asymmetric in favor of the test treatment (Test) over the reference treatment (Control). These trials are designed to compare the relative efficacy of Test to Control by reference to a clinically important margin, M....
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472861/ https://www.ncbi.nlm.nih.gov/pubmed/28619049 http://dx.doi.org/10.1186/s13063-017-2024-2 |